Dietary factors and DNA methylation-based markers of ageing in 5310 middle-aged and older Australian adults

L Cribb; AM Hodge; MC Southey; GG Giles; RL Milne; PA Dugué

Journal article

Dietary factors and DNA methylation-based markers of ageing in 5310 middle-aged and older Australian adults

L Cribb, AM Hodge, MC Southey, GG Giles, RL Milne, PA Dugué

Geroscience | Published : 2025

DOI: 10.1007/s11357-024-01341-7

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Abstract

The role of nutrition in healthy ageing is acknowledged but details of optimal dietary composition are still uncertain. We aimed to investigate the cross-sectional associations between dietary exposures, including macronutrient composition, food groups, specific foods, and overall diet quality, with methylation-based markers of ageing. Blood DNA methylation data from 5310 participants (mean age 59 years) in the Melbourne Collaborative Cohort Study were used to calculate five methylation-based measures of ageing: PCGrimAge, PCPhenoAge, DunedinPACE, ZhangAge, TelomereAge. For a range of dietary exposures, we estimated (i) the ‘equal-mass substitution effect’, which quantifies the effect of add..

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University of Melbourne Researchers

Allison Hodge Author

Melissa Southey Author

Graham Giles Author

Roger Milne Author

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Funding Acknowledgements

Open Access funding enabled and organized by CAUL and its Member Institutions. Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council (NHMRC) grants 209057, 396414, and 1074383 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the NHMRC Grants 1011618, 1026892, 1027505, 1050198, 1043616, and 1074383.